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A semi-quantitative food-frequency questionnaire was used to assess usual dietary habits. PA was assessed by using the International Physical Activity Questionnaire, validated for Italian women. Blood pressure was measured by using the auscultatory method. Body mass index was calculated as weight in kilograms divided by the square of height in meters. MS was defined according to the International Diabetes Federation criteria. BC incidence was evaluated for the entire study period (median follow-up period, 4.5 years). During follow-up, 181 incident cases of BC occurred. Compared with non-obese women, those with MS showed a marginally nonsignificant increased risk of BC (adjusted hazard ratio: 1.35, 95% confidence interval: 0.93-1.95, P = 0.11). 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